Severity of Dyskinesia and D3R Signaling Changes Induced by L-DOPA Treatment of Hemiparkinsonian Rats Are Features Inherent to the Treated Subjects

Severity of Dyskinesia and D3R Signaling Changes Induced by L-DOPA Treatment of Hemiparkinsonian Rats Are Features Inherent to the Treated Subjects

Extensive damage to nigrostriatal dopaminergic neurons leads to Parkinson’s disease (PD). To date, the most effective treatment has been administration of levodopa (L-DOPA) to increase dopaminergic tone. This treatment leads to responses that vary widely among patients, from predominantly...

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Bibliographic Details
Main Authors: Sacnité Albarrán-Bravo, José Arturo Ávalos-Fuentes, Hernán Cortés, Marina Rodriguez-Sánchez, Norberto Leyva-García, Claudia Rangel-Barajas, David Erlij, Benjamín Florán
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Biomolecules
Subjects:
dopamine 3 receptors
dopamine 1 receptors
parkinson’s disease
dyskinesia
basal ganglia
substantia nigra pars reticulata
Online Access:https://www.mdpi.com/2218-273X/9/9/431

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https://www.mdpi.com/2218-273X/9/9/431

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