Microbial Metabolite Sodium Butyrate Attenuates Cartilage Degradation by Restoring Impaired Autophagy and Autophagic Flux in Osteoarthritis Development

Microbial Metabolite Sodium Butyrate Attenuates Cartilage Degradation by Restoring Impaired Autophagy and Autophagic Flux in Osteoarthritis Development

Osteoarthritis (OA) is a degenerative joint disease with multiple etiologies that affects individuals worldwide. No effective interventions are currently available to reverse the pathological process of OA. Sodium butyrate (NaB), a component of short-chain fatty acids (SCFAs), has multiple biologica...

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Bibliographic Details
Main Authors: Haikang Zhou, Guoqing Li, Yang Wang, Rendong Jiang, Yicheng Li, Huhu Wang, Fei Wang, Hairong Ma, Li Cao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
sodium butyrate
osteoarthritis
autophagy
apoptosis
oxidative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.659597/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.659597/full

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