Quantitative Analysis of the Membrane Affinity of Local Anesthetics Using a Model Cell Membrane

Quantitative Analysis of the Membrane Affinity of Local Anesthetics Using a Model Cell Membrane

Local anesthesia is a drug that penetrates the nerve cell membrane and binds to the voltage gate sodium channel, inhibiting the membrane potential and neurotransmission. It is mainly used in clinical uses to address the pain of surgical procedures in the local area. Local anesthetics (LAs), however,...

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Bibliographic Details
Main Authors: Wanjae Choi, Hyunil Ryu, Ahmed Fuwad, Seulmini Goh, Chaoge Zhou, Jiwook Shim, Masahiro Takagi, Soonjo Kwon, Sun Min Kim, Tae-Joon Jeon
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Membranes
Subjects:
local anesthetics
membrane affinity
lipid bilayer membrane
calorimetric assay
cramicidin A
fibroblast cells
Online Access:https://www.mdpi.com/2077-0375/11/8/579

Internet

https://www.mdpi.com/2077-0375/11/8/579

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