Pharmacodynamic Monitoring of RO5459072, a Small Molecule Inhibitor of Cathepsin S

Pharmacodynamic Monitoring of RO5459072, a Small Molecule Inhibitor of Cathepsin S

Major histocompatibility complex class II (MHCII)-restricted antigen priming of CD4+ T cells is both involved in adaptive immune responses and the pathogenesis of autoimmune diseases. Degradation of invariant chain Ii, a protein that prevents premature peptide loading, is a prerequisite for nascent...

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Bibliographic Details
Main Authors: Michel Theron, Darren Bentley, Sandra Nagel, Marianne Manchester, Michael Gerg, Thomas Schindler, Ana Silva, Barbara Ecabert, Priscila Teixeira, Camille Perret, Bernhard Reis
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Immunology
Subjects:
cathepsin S
pharmacodynamic
biomarker
clinical
neoepitope
major histocompatibility complex class II
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00806/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00806/full

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