Granulocyte-Colony Stimulating Factor-Overexpressing Mesenchymal Stem Cells Exhibit Enhanced Immunomodulatory Actions Through the Recruitment of Suppressor Cells in Experimental Chagas Disease Cardiomyopathy

Granulocyte-Colony Stimulating Factor-Overexpressing Mesenchymal Stem Cells Exhibit Enhanced Immunomodulatory Actions Through the Recruitment of Suppressor Cells in Experimental Chagas Disease Cardiomyopathy

Genetic modification of mesenchymal stem cells (MSCs) is a promising strategy to improve their therapeutic effects. Granulocyte-colony stimulating factor (G-CSF) is a growth factor widely used in the clinical practice with known regenerative and immunomodulatory actions, including the mobilization o...

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Bibliographic Details
Main Authors: Daniela N. Silva, Bruno S. F. Souza, Juliana F. Vasconcelos, Carine M. Azevedo, Clarissa X. R. Valim, Bruno D. Paredes, Vinicius P. C. Rocha, Gisele B. Carvalho, Pamela S. Daltro, Simone G. Macambira, Carolina K. V. Nonaka, Ricardo Ribeiro-dos-Santos, Milena B. P. Soares
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
mesenchymal stem cells
granulocyte-colony stimulating factor
immunomodulation
Chagas disease
cardiomyopathy
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01449/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01449/full

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