VH Replacement Footprint Analyser-I (VHRFA-I), a Java based Computer Program for Analyses of Immunoglobulin Heavy Chain Genes and Potential VH Replacement Products in Human and Mouse

VH Replacement Footprint Analyser-I (VHRFA-I), a Java based Computer Program for Analyses of Immunoglobulin Heavy Chain Genes and Potential VH Replacement Products in Human and Mouse

VH replacement occurs through RAG-mediated secondary recombination between a rearranged VH gene and an upstream unrearranged VH gene. Due to the location of the cryptic Recombination Signal Sequence (cRSS, TACTGTG) at the 3’ end of VH gene coding region, a short stretch of nucleotides from the previ...

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Bibliographic Details
Main Authors: Lin eHuang, Miles D Lange, Zhixin eZhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-02-01
Series:Frontiers in Immunology
Subjects:
B cell
VDJ rearrangement
RAG
VH replacement
IGH sequencing
IgH gene
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00040/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00040/full

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