Characterization of a stable, hypertensive rat model suitable for the consecutive evaluation of human renin inhibitors

Characterization of a stable, hypertensive rat model suitable for the consecutive evaluation of human renin inhibitors

Introduction : The hypertensive double-transgenic (dTG) rat strain, expressing human renin and angiotensinogen, develops severe hypertension and organ damage and 50% of individuals die by 7 weeks of age. Here, we characterise a variation of this model in which animals present stable hypertension. Ma...

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Main Authors: René St-Jacques, Sylvie Toulmond, Anick Auger, Christoph Binkert, Wanda Cromlish, Walter Fischli, Jennifer Harris, Patrick Hess, Jie Lan, Susana Liu, Denis Riendeau, Beat Steiner, M David Percival
Format: Article
Language:English
Published: Hindawi - SAGE Publishing 2011-09-01
Series:Journal of the Renin-Angiotensin-Aldosterone System
Online Access:https://doi.org/10.1177/1470320310392618

Internet

https://doi.org/10.1177/1470320310392618

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