Smad2/4 Signaling Pathway Is Critical for Epidermal Langerhans Cell Repopulation Under Inflammatory Condition but Not Required for Their Homeostasis at Steady State

Smad2/4 Signaling Pathway Is Critical for Epidermal Langerhans Cell Repopulation Under Inflammatory Condition but Not Required for Their Homeostasis at Steady State

Epidermal Langerhans cells (LCs) are skin-resident dendritic cells that are essential for the induction of skin immunity and tolerance. Transforming growth factor-β 1 (TGFβ1) is a crucial factor for LC maintenance and function. However, the underlying TGFβ1 signaling pathways remain unclear. Our pre...

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Bibliographic Details
Main Authors: Linting Huang, Gui-Hua Li, Qian Yu, Yingping Xu, Steven Cvetkovski, Xuan Wang, Nirmal Parajuli, Imo Udo-Inyang, Daniel Kaplan, Li Zhou, Zhirong Yao, Qing-Sheng Mi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Immunology
Subjects:
Langerhans cells
Smad2
Smad3
Smad4
transforming growth factor-β1
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00912/full

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https://www.frontiersin.org/article/10.3389/fimmu.2020.00912/full

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