A Novel Phytochemical, DIM, Inhibits Proliferation, Migration, Invasion and TNF-α Induced Inflammatory Cytokine Production of Synovial Fibroblasts From Rheumatoid Arthritis Patients by Targeting MAPK and AKT/mTOR Signal Pathway

A Novel Phytochemical, DIM, Inhibits Proliferation, Migration, Invasion and TNF-α Induced Inflammatory Cytokine Production of Synovial Fibroblasts From Rheumatoid Arthritis Patients by Targeting MAPK and AKT/mTOR Signal Pathway

In rheumatoid arthritis(RA) pathogenesis, activated RA fibroblast-like synoviocytes (RA-FLSs) exhibit similar proliferative features as tumor cells and subsequent erosion to cartilage will eventually lead to joint destruction. Therefore, it is imperative to search for compounds, which can effectivel...

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Bibliographic Details
Main Authors: Hongyan Du, Xi Zhang, Yongchang Zeng, Xiaoming Huang, Hao Chen, Suihai Wang, Jing Wu, Qiang Li, Wei Zhu, Hongwei Li, Tiancai Liu, Qinghong Yu, Yingsong Wu, Ligang Jie
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Immunology
Subjects:
3′3-Diindolylmethane(DIM)
suppress
rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs)
adjuvant-induced arthritis (AIA)
MAPK
AKT/mTOR
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01620/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.01620/full

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