Fucoidan Prevents RANKL-Stimulated Osteoclastogenesis and LPS-Induced Inflammatory Bone Loss via Regulation of Akt/GSK3β/PTEN/NFATc1 Signaling Pathway and Calcineurin Activity

Fucoidan Prevents RANKL-Stimulated Osteoclastogenesis and LPS-Induced Inflammatory Bone Loss via Regulation of Akt/GSK3β/PTEN/NFATc1 Signaling Pathway and Calcineurin Activity

Excessive osteoclast differentiation and/or function plays a pivotal role in the pathogenesis of bone diseases such as osteoporosis and rheumatoid arthritis. Here, we examined whether fucoidan, a sulfated polysaccharide present in brown algae, attenuates receptor activator of nuclear factor-&#95...

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Bibliographic Details
Main Authors: Sheng-Hua Lu, Yi-Jan Hsia, Kuang-Chung Shih, Tz-Chong Chou
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Marine Drugs
Subjects:
fucoidan
RANKL
osteoclastogenesis
calcineurin
lipopolysaccharide
bone loss
Online Access:https://www.mdpi.com/1660-3397/17/6/345

Internet

https://www.mdpi.com/1660-3397/17/6/345

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