LMNA Mutations G232E and R482L Cause Dysregulation of Skeletal Muscle Differentiation, Bioenergetics, and Metabolic Gene Expression Profile

LMNA Mutations G232E and R482L Cause Dysregulation of Skeletal Muscle Differentiation, Bioenergetics, and Metabolic Gene Expression Profile

Laminopathies are a family of monogenic multi-system diseases resulting from mutations in the <i>LMNA</i> gene which include a wide range of neuromuscular disorders. Although lamins are expressed in most types of differentiated cells, LMNA mutations selectively affect only specific tissu...

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Bibliographic Details
Main Authors: Elena V. Ignatieva, Oksana A. Ivanova, Margarita Y. Komarova, Natalia V. Khromova, Dmitrii E. Polev, Anna A. Kostareva, Alexey Sergushichev, Renata I. Dmitrieva
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Genes
Subjects:
laminopathies
muscle dystrophies
LMNA G232E/R482L mutations
myogenesis
transcriptome sequencing
bioenergetics
Online Access:https://www.mdpi.com/2073-4425/11/9/1057

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https://www.mdpi.com/2073-4425/11/9/1057

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