Minor abnormalities of testis development in mice lacking the gene encoding the MAPK signalling component, MAP3K1.

Minor abnormalities of testis development in mice lacking the gene encoding the MAPK signalling component, MAP3K1.

In mammals, the Y chromosome is a dominant male determinant, causing the bipotential gonad to develop as a testis. Recently, cases of familial and spontaneous 46,XY disorders of sex development (DSD) have been attributed to mutations in the human gene encoding mitogen-activated protein kinase kinase...

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Bibliographic Details
Main Authors: Nick Warr, Debora Bogani, Pam Siggers, Rachel Brixey, Hilda Tateossian, Asha Dopplapudi, Sara Wells, Michael Cheeseman, Ying Xia, Harry Ostrer, Andy Greenfield
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-05-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21559298/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21559298/?tool=EBI

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