PDB-1 from Potentilla discolor Bunge induces apoptosis and autophagy by downregulating the PI3K/Akt/mTOR signaling pathway in A549 cells

PDB-1 from Potentilla discolor Bunge induces apoptosis and autophagy by downregulating the PI3K/Akt/mTOR signaling pathway in A549 cells

PDB-1 is a new C-27-carboxylated-lupane-triterpenoid derivative isolated from Potentilla discolor Bunge. In our previous research, PDB-1 was suggested to have an obvious selectivity for tumor cells. This study focused on clarifying PDB-1’s anticancer mechanism in the inhibition of proliferation and...

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Bibliographic Details
Main Authors: Rui-rui Zhang, Na-na Meng, Chao Liu, Kui-lin Li, Mu-xuan Wang, Zhi-bo Lv, Shu-ya Chen, Xu Guo, Xin-kun Wang, Qing Wang, Jin-yue Sun
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
PDB-1
Proliferation
Apoptosis
Autophagy
PI3K/Akt/mTOR
Molecular mechanism
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220305710

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http://www.sciencedirect.com/science/article/pii/S0753332220305710

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