ITPA Polymorphisms Are Associated with Hematological Side Effects during Antiviral Therapy for Chronic HCV Infection.

BACKGROUND/OBJECTIVE:Genetic polymorphisms in the inosine triphosphatase (ITPA) gene have been associated with the protection from early ribavirin(RBV)-induced hemolytic anemia among patients with chronic hepatitis C virus (HCV) infection. The aim of the present study was to investigate the associat...

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Main Authors: Raoel Maan, Adriaan J van der Meer, Willem Pieter Brouwer, Elisabeth P C Plompen, Milan J Sonneveld, Robert Roomer, Annemiek A van der Eijk, Zwier M A Groothuismink, Bettina E Hansen, Bart J Veldt, Harry L A Janssen, Andre Boonstra, Robert J de Knegt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4595504?pdf=render