The Clonal Expansion Dynamics of the HIV-1 Reservoir: Mechanisms of Integration Site-Dependent Proliferation and HIV-1 Persistence

The Clonal Expansion Dynamics of the HIV-1 Reservoir: Mechanisms of Integration Site-Dependent Proliferation and HIV-1 Persistence

More than 50% of the HIV-1 latent reservoir is maintained by clonal expansion. The clonally expanded HIV-1-infected cells can contribute to persistent nonsuppressible low-level viremia and viral rebound. HIV-1 integration site and proviral genome landscape profiling reveals the clonal expansion dyna...

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Bibliographic Details
Main Authors: Yang-Hui Jimmy Yeh, Kerui Yang, Anya Razmi, Ya-Chi Ho
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Viruses
Subjects:
HIV-1 latent reservoir
HIV-1 cure
clonal expansion
HIV-1 insertional mutagenesis
HIV-1 integration site-dependent proliferation
aberrant HIV-1 RNA splicing
Online Access:https://www.mdpi.com/1999-4915/13/9/1858

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https://www.mdpi.com/1999-4915/13/9/1858

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