An integrative pan-cancer investigation reveals common genetic and transcriptional alterations of AMPK pathway genes as important predictors of clinical outcomes across major cancer types

An integrative pan-cancer investigation reveals common genetic and transcriptional alterations of AMPK pathway genes as important predictors of clinical outcomes across major cancer types

Abstract Background The AMP-activated protein kinase (AMPK) is an evolutionarily conserved regulator of cellular energy homeostasis. As a nexus for transducing metabolic signals, AMPK cooperates with other energy-sensing pathways to modulate cellular responses to metabolic stressors. With metabolic...

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Bibliographic Details
Main Authors: Wai Hoong Chang, Alvina G. Lai
Format: Article
Language:English
Published: BMC 2020-08-01
Series:BMC Cancer
Subjects:
AMPK
Glioma
Loss-of-function
Tumor metabolism
Pan-cancer
Online Access:http://link.springer.com/article/10.1186/s12885-020-07286-2

Internet

http://link.springer.com/article/10.1186/s12885-020-07286-2

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