Silencing of mutant p53 by siRNA induces cell cycle arrest and apoptosis in human bladder cancer cells

Silencing of mutant p53 by siRNA induces cell cycle arrest and apoptosis in human bladder cancer cells

<p>Abstract</p> <p>Background</p> <p>p53 is the most frequently mutated tumor-suppressor gene in human cancers. It has been reported that mutations in p53 result not only in the loss of its ability as a tumor suppressor, but also in the gain of novel cancer-related func...

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Bibliographic Details
Main Authors: Zhu Hai-Bin, Yang Kai, Xie Yan-Qi, Lin Yi-Wei, Mao Qi-Qi, Xie Li-Ping
Format: Article
Language:English
Published: BMC 2013-01-01
Series:World Journal of Surgical Oncology
Subjects:
Mutant p53
RNA interference
Bladder cancer
Cisplatin
Apoptosis
Online Access:http://www.wjso.com/content/11/1/22

Internet

http://www.wjso.com/content/11/1/22

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