Dysregulation of cell polarity proteins synergize with oncogenes or the microenvironment to induce invasive behavior in epithelial cells.

Changes in expression and localization of proteins that regulate cell and tissue polarity are frequently observed in carcinoma. However, the mechanisms by which changes in cell polarity proteins regulate carcinoma progression are not well understood. Here, we report that loss of polarity protein exp...

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Bibliographic Details
Main Authors: Samit Chatterjee, Laurie Seifried, Michael E Feigin, Don L Gibbons, Claudio Scuoppo, Wei Lin, Zain H Rizvi, Evan Lind, Dilan Dissanayake, Jonathan Kurie, Pam Ohashi, Senthil K Muthuswamy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3329530?pdf=render