Mitochondrial Calcium Uniporter Deficiency in Zebrafish Causes Cardiomyopathy With Arrhythmia

Mitochondrial Calcium Uniporter Deficiency in Zebrafish Causes Cardiomyopathy With Arrhythmia

Mitochondrial Ca2 + uptake influences energy production, cell survival, and Ca2 + signaling. The mitochondrial calcium uniporter, MCU, is the primary route for uptake of Ca2 + into the mitochondrial matrix. We have generated a zebrafish MCU mutant that survives to adulthood and exhibits dramatic car...

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Bibliographic Details
Main Authors: Adam D. Langenbacher, Hirohito Shimizu, Welkin Hsu, Yali Zhao, Alexandria Borges, Carla Koehler, Jau-Nian Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Physiology
Subjects:
mitochondria
cardiomyopathy
arrhythmia
mitochondrial calcium uptake
sinus arrest
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2020.617492/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2020.617492/full

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