Polygenic analysis of inflammatory disease variants and effects on microglia in the aging brain

Polygenic analysis of inflammatory disease variants and effects on microglia in the aging brain

Abstract Background The role of the innate immune system in Alzheimer’s disease (AD) and neurodegenerative disease susceptibility has recently been highlighted in genetic studies. However, we do not know whether risk for inflammatory disease predisposes unaffected individuals to late-life cognitive...

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Bibliographic Details
Main Authors: Daniel Felsky, Ellis Patrick, Julie A. Schneider, Sara Mostafavi, Chris Gaiteri, Nikolaos Patsopoulos, David A. Bennett, Philip L. De Jager
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Molecular Neurodegeneration
Subjects:
Genomics
Alzheimer’s disease
Microglia
Inflammation
Polygenic score
Innate immunity
Online Access:http://link.springer.com/article/10.1186/s13024-018-0272-6

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http://link.springer.com/article/10.1186/s13024-018-0272-6

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