Identification of neutrophil β2-integrin LFA-1 as a potential mechanistic biomarker in ANCA-associated vasculitis via microarray and validation analyses

Identification of neutrophil β2-integrin LFA-1 as a potential mechanistic biomarker in ANCA-associated vasculitis via microarray and validation analyses

Abstract Background Leukocyte activation by anti-neutrophil cytoplasmic antibody (ANCA) and the subsequent leukocyte–endothelium interaction play a key role in the development of endothelial damage in ANCA-associated vasculitis (AAV). In contrast to that of leukocyte activation, the exact role of th...

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Bibliographic Details
Main Authors: Kotaro Matsumoto, Takahiko Kurasawa, Keiko Yoshimoto, Katsuya Suzuki, Tsutomu Takeuchi
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Arthritis Research & Therapy
Subjects:
ANCA-associated vasculitis
Gene expression
β2-integrin
Lymphocyte function-associated antigen-1
Online Access:https://doi.org/10.1186/s13075-021-02510-1

Internet

https://doi.org/10.1186/s13075-021-02510-1

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