Type I IFN Induction via Poly-ICLC Protects Mice against Cryptococcosis.

Cryptococcus neoformans is the most common cause of fungal meningoencephalitis in AIDS patients. Depletion of CD4 cells, such as occurs during advanced AIDS, is known to be a critical risk factor for developing cryptococcosis. However, the role of HIV-induced innate inflammation in susceptibility to...

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Bibliographic Details
Main Authors: Edward Sionov, Katrin D Mayer-Barber, Yun C Chang, Keith D Kauffman, Michael A Eckhaus, Andres M Salazar, Daniel L Barber, Kyung J Kwon-Chung
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-08-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4529209?pdf=render