Relationship of Brain Glutamate Response to D-Cycloserine and Lurasidone to Antidepressant Response in Bipolar Depression: A Pilot Study

Relationship of Brain Glutamate Response to D-Cycloserine and Lurasidone to Antidepressant Response in Bipolar Depression: A Pilot Study

N-methyl-D-aspartate glutamate-receptor (NMDAR) antagonists such as ketamine have demonstrated efficacy in both major depressive disorder (MDD) and bipolar disorder depression (BP-D). We have previously reported that reduction in Glx (glutamate + glutamine) in the ventromedial prefrontal cortex/ante...

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Bibliographic Details
Main Authors: Zhengchao Dong, Michael F. Grunebaum, Martin J. Lan, Vashti Wagner, Tse-Hwei Choo, Matthew S. Milak, Tarek Sobeih, J. John Mann, Joshua T. Kantrowitz
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Psychiatry
Subjects:
N-methyl-D-aspartate
glutamate
MRS—1H nuclear magnetic resonance spectra
biomarker
bipolar depression
D-Cycloserine
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2021.653026/full

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https://www.frontiersin.org/articles/10.3389/fpsyt.2021.653026/full

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