Tgf-beta downregulation of distinct chloride channels in cystic fibrosis-affected epithelia.

Tgf-beta downregulation of distinct chloride channels in cystic fibrosis-affected epithelia.

The cystic fibrosis transmembrane conductance regulator (CFTR) and Calcium-activated Chloride Conductance (CaCC) each play critical roles in maintaining normal hydration of epithelial surfaces including the airways and colon. TGF-beta is a genetic modifier of cystic fibrosis (CF), but how it influen...

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Bibliographic Details
Main Authors: Hongtao Sun, William T Harris, Stephanie Kortyka, Kavitha Kotha, Alicia J Ostmann, Amir Rezayat, Anusha Sridharan, Yan Sanders, Anjaparavanda P Naren, John P Clancy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4182049?pdf=render

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http://europepmc.org/articles/PMC4182049?pdf=render

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