The H2B deubiquitinase Usp22 promotes antibody class switch recombination by facilitating non-homologous end joining

The H2B deubiquitinase Usp22 promotes antibody class switch recombination by facilitating non-homologous end joining

Class switch recombination (CSR) requires break and repair of immunoglobulin DNA. Here the authors show that the histone deubiquitinase Usp22 is involved in V(D)J recombination and CSR of IgG and IgE, but not IgA, and that IgG CSR is dependent on the canonical c-NHEJ pathway, whereas IgA CSR is more...

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Bibliographic Details
Main Authors: Conglei Li, Thergiory Irrazabal, Clare C. So, Maribel Berru, Likun Du, Evelyn Lam, Alexanda K. Ling, Jennifer L. Gommerman, Qiang Pan-Hammarström, Alberto Martin
Format: Article
Language:English
Published: Nature Publishing Group 2018-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03455-x

Internet

https://doi.org/10.1038/s41467-018-03455-x

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