<it>In vivo </it>antinociception of potent mu opioid agonist tetrapeptide analogues and comparison with a compact opioid agonist - neurokinin 1 receptor antagonist chimera

<it>In vivo </it>antinociception of potent mu opioid agonist tetrapeptide analogues and comparison with a compact opioid agonist - neurokinin 1 receptor antagonist chimera

<p>Abstract</p> <p>Background</p> <p>An important limiting factor in the development of centrally acting pharmaceuticals is the blood-brain barrier (BBB). Transport of therapeutic peptides through this highly protective physiological barrier remains a challenge for pept...

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Bibliographic Details
Main Authors: Guillemyn Karel, Kleczkowska Patrycja, Novoa Alexandre, Vandormael Bart, Van den Eynde Isabelle, Kosson Piotr, Asim Muhammad, Schiller Peter W, Spetea Mariana, Lipkowski Andrzej W, Tourwé Dirk, Ballet Steven
Format: Article
Language:English
Published: BMC 2012-01-01
Series:Molecular Brain
Subjects:
Opioid tetrapeptides
dual opioid agonist - neurokinin antagonist peptidomimetic
tolerance studies
Online Access:http://www.molecularbrain.com/content/5/1/4

Internet

http://www.molecularbrain.com/content/5/1/4

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