Opposite effects of the S4-S5 linker and PIP2 on voltage-gated channel function: KCNQ1/KCNE1 and other channels

Opposite effects of the S4-S5 linker and PIP2 on voltage-gated channel function: KCNQ1/KCNE1 and other channels

Voltage-gated potassium (Kv) channels are tetramers, each subunit presenting six transmembrane segments (S1-S6), with each S1-S4 segments forming a voltage-sensing domain (VSD) and the four S5-S6 forming both the conduction pathway and its gate. S4 segments control the opening of the intracellular a...

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Bibliographic Details
Main Authors: Frank S Choveau, Fayal eAbderemane-Ali, Fabien C Coyan, Zeineb eEs-Salah-Lamoureux, Isabelle eBaro, Gildas eLoussouarn
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-07-01
Series:Frontiers in Pharmacology
Subjects:
Channelopathies
S4-S5 linker
patch-clamp
5-bisphosphate
Phosphatidylinositol 4
S4-S linker
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00125/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00125/full

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