Interleukin-37 Inhibits Colon Carcinogensis During Chronic Colitis

Interleukin-37 Inhibits Colon Carcinogensis During Chronic Colitis

Inflammatory bowel disease increases the risk of developing colon cancer. Interleukin (IL-) 37 is a fundamental inhibitor of innate immunity by reducing systemic and local inflammation. IL-37 protein is expressed in healthy and diseased bowel and liver tissue. Here, we tested whether transgenic expr...

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Bibliographic Details
Main Authors: Steffeni Mountford, Andrea Ringleb, Rahel Schwaiger, Doris Mayr, Sebastian Kobold, Charles A. Dinarello, Philip Bufler
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Immunology
Subjects:
chronic colitis
carcinogenesis
cytokines
inflammation
IL-37
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02632/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02632/full

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