Molecular mechanism of cardol, isolated from Trigona incisa stingless bee propolis, induced apoptosis in the SW620 human colorectal cancer cell line

Molecular mechanism of cardol, isolated from Trigona incisa stingless bee propolis, induced apoptosis in the SW620 human colorectal cancer cell line

Abstract Background Cardol is a major bioactive constituent in the Trigona incisa propolis from Indonesia, with a strong in vitro antiproliferative activity against the SW620 colorectal adenocarcinoma cell line (IC50 of 4.51 ± 0.76 μg/mL). Cardol induced G0/G1 cell cycle arrest and apoptotic cell de...

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Bibliographic Details
Main Authors: Paula Mariana Kustiawan, Kriengsak Lirdprapamongkol, Tanapat Palaga, Songchan Puthong, Preecha Phuwapraisirisan, Jisnuson Svasti, Chanpen Chanchao
Format: Article
Language:English
Published: BMC 2017-05-01
Series:BMC Pharmacology and Toxicology
Subjects:
Apoptosis
Cardol
Mitochondrial apoptotic pathway
Propolis
SW620 cancer cells
Online Access:http://link.springer.com/article/10.1186/s40360-017-0139-4

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http://link.springer.com/article/10.1186/s40360-017-0139-4

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