Identification of functional networks of estrogen- and c-Myc-responsive genes and their relationship to response to tamoxifen therapy in breast cancer.

Identification of functional networks of estrogen- and c-Myc-responsive genes and their relationship to response to tamoxifen therapy in breast cancer.

BACKGROUND: Estrogen is a pivotal regulator of cell proliferation in the normal breast and breast cancer. Endocrine therapies targeting the estrogen receptor are effective in breast cancer, but their success is limited by intrinsic and acquired resistance. METHODOLOGY/PRINCIPAL FINDINGS: With the go...

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Main Authors: Elizabeth A Musgrove, C Marcelo Sergio, Sherene Loi, Claire K Inman, Luke R Anderson, M Chehani Alles, Mark Pinese, C Elizabeth Caldon, Judith Schütte, Margaret Gardiner-Garden, Christopher J Ormandy, Grant McArthur, Alison J Butt, Robert L Sutherland
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2496892?pdf=render

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http://europepmc.org/articles/PMC2496892?pdf=render

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