Exclusive Temporal Stimulation of IL-10 Expression in LPS-Stimulated Mouse Macrophages by cAMP Inducers and Type I Interferons

Exclusive Temporal Stimulation of IL-10 Expression in LPS-Stimulated Mouse Macrophages by cAMP Inducers and Type I Interferons

Expression of the key anti-inflammatory cytokine IL-10 in lipopolysaccharide (LPS)-stimulated macrophages is mediated by a delayed autocrine/paracrine loop of type I interferons (IFN) to ensure timely attenuation of inflammation. We have previously shown that cAMP synergizes with early IL-10 express...

Full description

Bibliographic Details
Main Authors: Orna Ernst, Yifat Glucksam-Galnoy, Bibek Bhatta, Muhammad Athamna, Iris Ben-Dror, Yair Glick, Doron Gerber, Tsaffrir Zor
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
IL-10 promoter
cAMP
type I interferons
IL-10 expression
lipopolysaccharide
cAMP response element
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01788/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01788/full

Similar Items