In Vivo Bone Effects of a Novel Bisphosphonate‐EP4a Conjugate Drug (C3) for Reversing Osteoporotic Bone Loss in an Ovariectomized Rat Model

In Vivo Bone Effects of a Novel Bisphosphonate‐EP4a Conjugate Drug (C3) for Reversing Osteoporotic Bone Loss in an Ovariectomized Rat Model

ABSTRACT Pathological bone loss is a regular feature of postmenopausal osteoporosis, and the microstructural changes along with the bone loss make the individual prone to getting hip, spine, and wrist fractures. We have developed a new conjugate drug named C3, which has a synthetic, stable EP4 agoni...

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Bibliographic Details
Main Authors: Zeeshan Sheikh, Gang Chen, Faik Al‐Jaf, Marion Thévenin, Kate Banks, Michael Glogauer, Robert N Young, Marc D Grynpas
Format: Article
Language:English
Published: Wiley 2019-12-01
Series:JBMR Plus
Subjects:
ANABOLICS
BIOMECHANICS
BONE HISTOMORPHOMETRY
OSTEOPOROSIS
PRECLINICAL STUDIES
Online Access:https://doi.org/10.1002/jbm4.10237

Internet

https://doi.org/10.1002/jbm4.10237

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