Comprehensive fitness maps of Hsp90 show widespread environmental dependence

Gene-environment interactions have long been theorized to influence molecular evolution. However, the environmental dependence of most mutations remains unknown. Using deep mutational scanning, we engineered yeast with all 44,604 single codon changes encoding 14,160 amino acid variants in Hsp90 and...

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Bibliographic Details
Main Authors: Julia M Flynn, Ammeret Rossouw, Pamela Cote-Hammarlof, Inês Fragata, David Mavor, Carl Hollins III, Claudia Bank, Daniel NA Bolon
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-03-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/53810