IDO2 in immunomodulation and autoimmunity

IDO2 in immunomodulation and autoimmunity

IDO2 is a relative of IDO1 implicated in tryptophan catabolism and immune modulation but its specific contributions to normal physiology and pathophysiology are not known. Evolutionary genetic studies suggest that IDO2 has a unique function ancestral to IDO1. In mice, IDO2 gene deletion does not app...

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Bibliographic Details
Main Authors: George ePrendergast, Richard eMetz, Alexander J. Muller, Lauren M.F. Merlo, Laura eMandik-Nayak
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-11-01
Series:Frontiers in Immunology
Subjects:
Autoimmunity
tolerance
Aryl hydrocarbon receptor (AhR)
rheumatoid arthritis (RA)
kynurenine pathway
indoleamine dioxygenase
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00585/full

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http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00585/full

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