Biochemical criteria of toxicity of therapy with high doses of methotrexate in children with osteosarcoma
Methotrexate (Mtx) is a cytotoxic drug from the group of antimetabolites, folic acid antagonists. High-dose (HD) Mtx in pediatric oncology are used for the treatment of osteosarcoma (OS), and other types of tumors. This therapy has allowed to achieve a five-year relapse-free survival rates up to 80...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
ABV-press
2015-06-01
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| Series: | Uspehi Molekulârnoj Onkologii |
| Subjects: | |
| Online Access: | https://umo.abvpress.ru/jour/article/view/8 |