Role of Pancreatic Stellate Cells in Chemoresistance in Pancreatic Cancer

Role of Pancreatic Stellate Cells in Chemoresistance in Pancreatic Cancer

Pancreatic cancer is highly chemoresistant. A major contributing factor is the characteristic extensive stromal or fibrotic reaction, which comprises up to 90% of the tumour volume. Over the last decade there has been intensive research into the role of the pro-fibrogenic pancreatic stellate cells (...

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Bibliographic Details
Main Authors: Joshua eMcCarroll, Stephanie eNaim, George eSharbeen, Nelson eRussia, Julia eLee, Maria eKavallaris, David eGoldstein, Phoebe ePhillips
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-04-01
Series:Frontiers in Physiology
Subjects:
Fibrosis
Pancreatic Stellate Cells
Pancreatic Cancer
chemoresistance
Stroma
hypoxia.
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00141/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00141/full

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