Anti-Leishmanial and Cytotoxic Activities of a Series of Maleimides: Synthesis, Biological Evaluation and Structure-Activity Relationship

In the present study, 45 maleimides have been synthesized and evaluated for anti-leishmanial activities against <i>L. donovani</i> in vitro and cytotoxicity toward THP1 cells. All compounds exhibited obvious anti-leishmanial activities. Among the tested compounds, there were 10 maleimide...

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Bibliographic Details
Main Authors: Yongxian Fan, Yuele Lu, Xiaolong Chen, Babu Tekwani, Xing-Cong Li, Yinchu Shen
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Molecules
Subjects:
SAR
Online Access:https://www.mdpi.com/1420-3049/23/11/2878