PRMT2 links histone H3R8 asymmetric dimethylation to oncogenic activation and tumorigenesis of glioblastoma

PRMT2 links histone H3R8 asymmetric dimethylation to oncogenic activation and tumorigenesis of glioblastoma

The role of protein arginine methyltransferases (PRMTs) in epigenetic regulation in cancer is still poorly understood. Here, the authors show that PRMT2 is highly expressed in Glioblastoma multiforme (GBM) and provide evidence that PRMT2 acts as a transcriptional co-activator for oncogenic gene expr...

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Bibliographic Details
Main Authors: Feng Dong, Qian Li, Chao Yang, Dawei Huo, Xing Wang, Chunbo Ai, Yu Kong, Xiaoyu Sun, Wen Wang, Yan Zhou, Xing Liu, Wei Li, Weiwei Gao, Wen Liu, Chunsheng Kang, Xudong Wu
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06968-7

Internet

https://doi.org/10.1038/s41467-018-06968-7

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