Androgen-Independent Prostate Cancer: Potential Role of Androgen and ErbB Receptor Signal Transduction Crosstalk

• Main Authors: Soha Salama El Sheikh, Jan Domin, Paul Abel, Gordon Stamp, El-Nasir Lalani
• Format: Article
• Language: English
• Published: Elsevier 2003-03-01
• Series: Neoplasia: An International Journal for Oncology Research
• Subjects: androgen receptor; ErbB receptors; MAPK; prostate cancer; AKT
• Online Access: http://www.sciencedirect.com/science/article/pii/S1476558603800015

In prostate cancer (PC), increasing evidence suggests that androgen receptor (AR) signalling is functional under conditions of maximal androgen blockade. PC cells survive and proliferate in the altered hormonal environment possibly by interactions between growth factor-activated pathways and AR signalling. The present review article summarizes the current evidence of this crosstalk and focuses on the interactions among the ErbB receptor network, its downstream pathways, the AR. The potential role of this crosstalk in the development of androgen independence and in relation to antiandrogen therapy is discussed. Such interactions provide insight into possible complementary or additional strategies in the management of PC.