Synthesis, ex Vivo and in Vitro Hydrolysis Study of an Indoline Derivative Designed as an Anti-Inflammatory with Reduced Gastric Ulceration Properties

Synthesis, ex Vivo and in Vitro Hydrolysis Study of an Indoline Derivative Designed as an Anti-Inflammatory with Reduced Gastric Ulceration Properties

The compound 1-(2,6-dichlorophenyl)indolin-2-one (1), planned as a pro-drug of diclofenac (2), was easily synthesized in 94% yield by an intramolecular reaction in the presence of coupling agent (i.e., EDC). Compound 1 showed anti-inflammatory and analgesic activity without gastro-ulcerogenic effect...

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Bibliographic Details
Main Authors: Man Chin Chung, Jean Leandro dos Santos, Ednir Vizioli Oliveira, Lorena Blau, Renato Farina Menegon, Rosângela Gonçalves Peccinini
Format: Article
Language:English
Published: MDPI AG 2009-08-01
Series:Molecules
Subjects:
indolinone
pro-drug
anti-inflammatory
hydrolysis
diclofenac
Online Access:http://www.mdpi.com/1420-3049/14/9/3187/

Internet

http://www.mdpi.com/1420-3049/14/9/3187/

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