The Downstream Regulation of Chemokine Receptor Signalling: Implications for Atherosclerosis

Heterotrimeric G-protein-coupled receptors (GPCRs) are key mediators of intracellular signalling, control numerous physiological processes, and are one of the largest class of proteins to be pharmacologically targeted. Chemokine-induced macrophage recruitment into the vascular wall is an early patho...

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Bibliographic Details
Main Authors: Jyoti Patel, Keith M. Channon, Eileen McNeill
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/2013/459520