Anti-Melanogenic Effect of Dendropanax morbiferus and Its Active Components via Protein Kinase A/Cyclic Adenosine Monophosphate-Responsive Binding Protein- and p38 Mitogen-Activated Protein Kinase-Mediated Microphthalmia−Associated Transcription Factor Downregulation

Anti-Melanogenic Effect of Dendropanax morbiferus and Its Active Components via Protein Kinase A/Cyclic Adenosine Monophosphate-Responsive Binding Protein- and p38 Mitogen-Activated Protein Kinase-Mediated Microphthalmia−Associated Transcription Factor Downregulation

Dendropanax morbiferus H. Lév has been reported to have some pharmacologic activities and also interested in functional cosmetics. We found that the water extract of D. morbiferus leaves significantly inhibited tyrosinase activity and melanin formation in α-melanocyte stimulating hormone (MSH)-induc...

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Bibliographic Details
Main Authors: Jung Up Park, Seo Young Yang, Rui Hong Guo, Hong Xu Li, Young Ho Kim, Young Ran Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Pharmacology
Subjects:
Dendropanax morbiferus
(10E)-9,16-dihydroxyoctadeca-10,17-dien-12,14-diynoate
anti-melanogenesis
tyrosinase
PKA/CREB
p-p38/p38
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00507/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00507/full

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