E6 Oncoproteins from High-Risk Human Papillomavirus Induce Mitochondrial Metabolism in a Head and Neck Squamous Cell Carcinoma Model

E6 Oncoproteins from High-Risk Human Papillomavirus Induce Mitochondrial Metabolism in a Head and Neck Squamous Cell Carcinoma Model

Head and neck squamous cell carcinoma (HNSCC) cells that are positive for human papillomavirus (HPV+) favor mitochondrial metabolism rather than glucose metabolism. However, the involvement of mitochondrial metabolism in HNSCC HPV+ cells is still unknown. The aim of this work was to evaluate the rol...

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Bibliographic Details
Main Authors: Alfredo Cruz-Gregorio, Ana Karina Aranda-Rivera, Omar Emiliano Aparicio-Trejo, Iris Coronado-Martínez, José Pedraza-Chaverri, Marcela Lizano
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Biomolecules
Subjects:
HNSCC
HPV16 and HPV18 E6 oncoproteins
mitochondrial metabolism
oxidative stress
DNA damage
cellular respiration
mitochondrial decoupling
oxidative phosphorylation
Online Access:https://www.mdpi.com/2218-273X/9/8/351

Internet

https://www.mdpi.com/2218-273X/9/8/351

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