Targeted Disruption of the Cln3 Gene Provides a Mouse Model for Batten Disease

Targeted Disruption of the Cln3 Gene Provides a Mouse Model for Batten Disease

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Batten disease, a degenerative neurological disorder with juvenile onset, is the most common form of the neuronal ceroid lipofuscinoses. Mutations in the CLN3 gene cause Batten disease. To facilitate studies of Batten disease pathogenesis and treatment, a murine model was created by targeted disrupt...

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Bibliographic Details
Main Authors: Hannah M. Mitchison, David J. Bernard, Nicholas D.E. Greene, Jonathan D. Cooper, Mohammed A. Junaid, Raju K. Pullarkat, Nanneke de Vos, Martijn H. Breuning, Jennie W. Owens, William C. Mobley, R.Mark Gardiner, Brian D. Lake, Peter E.M. Taschner, Robert L. Nussbaum
Format: Article
Language:English
Published: Elsevier 1999-10-01
Series:Neurobiology of Disease
Online Access:http://www.sciencedirect.com/science/article/pii/S096999619990267X

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http://www.sciencedirect.com/science/article/pii/S096999619990267X

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