Complexin inhibits spontaneous release and synchronizes Ca2+-triggered synaptic vesicle fusion by distinct mechanisms

Complexin inhibits spontaneous release and synchronizes Ca2+-triggered synaptic vesicle fusion by distinct mechanisms

Previously we showed that fast Ca2+-triggered vesicle fusion with reconstituted neuronal SNAREs and synaptotagmin-1 begins from an initial hemifusion-free membrane point contact, rather than a hemifusion diaphragm, using a single vesicle–vesicle lipid/content mixing assay (Diao et al., 2012). When c...

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Bibliographic Details
Main Authors: Ying Lai, Jiajie Diao, Daniel J Cipriano, Yunxiang Zhang, Richard A Pfuetzner, Mark S Padolina, Axel T Brunger
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-08-01
Series:eLife
Subjects:
synaptic vesicle fusion
neurotransmitter release
complexin
synaptotagmin
SNARE
membrane fusion
Online Access:https://elifesciences.org/articles/03756

Internet

https://elifesciences.org/articles/03756

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