Targeting of mutant p53 and the cellular redox balance by APR-246 as a strategy for efficient cancer therapy

Targeting of mutant p53 and the cellular redox balance by APR-246 as a strategy for efficient cancer therapy

TP53 is the most frequently mutated gene in cancer. The p53 protein activates transcription of genes that promote cell cycle arrest or apoptosis, or regulate cell metabolism and other processes . Missense mutations in TP53 abolish specific DNA binding of p53 and allow evasion of apoptosis and accele...

Full description

Bibliographic Details
Main Authors: Vladimir J.N. Bykov, Qiang eZhang, Meiqiongzi eZhang, Sophia eCeder, Lars eAbrahmsen, Klas G Wiman
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-02-01
Series:Frontiers in Oncology
Subjects:
Apoptosis
Glutathione
cancer therapy
Clinical Trial
mutant p53
thioredoxin reductase
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2016.00021/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2016.00021/full

Similar Items