Synergistic Anti-arrhythmic Effects in Human Atria with Combined Use of Sodium Blockers and Acacetin

Synergistic Anti-arrhythmic Effects in Human Atria with Combined Use of Sodium Blockers and Acacetin

Atrial fibrillation (AF) is the most common cardiac arrhythmia. Developing effective and safe anti-AF drugs remains an unmet challenge. Simultaneous block of both atrial-specific ultra-rapid delayed rectifier potassium (K+) current (IKur) and the Na+ current (INa) has been hypothesized to be anti-AF...

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Bibliographic Details
Main Authors: Haibo Ni, Dominic G. Whittaker, Wei Wang, Wayne R. Giles, Sanjiv M. Narayan, Henggui Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Physiology
Subjects:
atrial-selective block
atrial fibrillation
sodium and potassium current block
multiscale simulation
synergistic antiarrhythmic effect
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00946/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2017.00946/full

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