Two novel α7 nicotinic acetylcholine receptor ligands: in vitro properties and their efficacy in collagen-induced arthritis in mice.

Two novel α7 nicotinic acetylcholine receptor ligands: in vitro properties and their efficacy in collagen-induced arthritis in mice.

INTRODUCTION:The cholinergic anti-inflammatory pathway can downregulate inflammation via the release of acetylcholine (ACh) by the vagus nerve. This neurotransmitter binds to the α7 subunit of nicotinic acetylcholine receptors (α7nAChR), expressed on macrophages and other immune cells. We tested the...

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Main Authors: Marjolein A van Maanen, Roger L Papke, Frieda A Koopman, Jessica Koepke, Lisette Bevaart, Roger Clark, Diana Lamppu, Daniel Elbaum, Gregory J LaRosa, Paul P Tak, Margriet J Vervoordeldonk
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4305287?pdf=render

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http://europepmc.org/articles/PMC4305287?pdf=render

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