A comparison of vitamin A and leucovorin for the prevention of methotrexate-induced micronuclei production in rat bone marrow

A comparison of vitamin A and leucovorin for the prevention of methotrexate-induced micronuclei production in rat bone marrow

INTRODUCTION: Methotrexate, a folate antagonist, is a mainstay treatment for childhood acute lymphoblastic leukemia. It is also widely used in a low dose formulation to treat patients with rheumatoid arthritis. In rats, methotrexate is known to induce micronuclei formation, leading to genetic damage...

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Bibliographic Details
Main Authors: Sampath Madhyastha, Latha V Prabhu, V Saralaya, Rajalakshmi Rai
Format: Article
Language:English
Published: Faculdade de Medicina / USP 2008-01-01
Series:Clinics
Subjects:
Micronuclei
Rat bone marrow erythrocytes
Methotrexate
Vitamin A
Leucovorin
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322008000600019

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