A comparison of vitamin A and leucovorin for the prevention of methotrexate-induced micronuclei production in rat bone marrow
INTRODUCTION: Methotrexate, a folate antagonist, is a mainstay treatment for childhood acute lymphoblastic leukemia. It is also widely used in a low dose formulation to treat patients with rheumatoid arthritis. In rats, methotrexate is known to induce micronuclei formation, leading to genetic damage...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Faculdade de Medicina / USP
2008-01-01
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| Series: | Clinics |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322008000600019 |